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Open Access Short report

Short communication: genetic variations of SLC2A9 in relation to Parkinson’s disease

Jianjun Gao1, Hong Xu2, Xuemei Huang3 and Honglei Chen1*

Author Affiliations

1 Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

2 Molecular Genetics Core Facility, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

3 Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA

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Translational Neurodegeneration 2013, 2:5  doi:10.1186/2047-9158-2-5

Published: 19 February 2013

Abstract

Background

Epidemiological studies showed that higher plasma urate was associated with lower risk for Parkinson’s disease (PD) and slower disease progression. Recent genome-wide association studies (GWAS) consistently showed that several single nucleotide polymorphisms (SNPs) in the solute carrier family 2 member 9 gene (SLC2A9 ) were associated with plasma urate concentration and the risk of gout.

Methods

We conducted a case–control study to examine twelve tag SNPs of the SLC2A9 gene in relation to PD among 788 cases and 911 controls of European ancestry. Odds ratios (OR) and 95% confidence intervals (CI) were derived from logistic regression models, adjusting for age, sex, smoking and caffeine consumption.

Results

These SNPs were all in linkage disequilibrium (R2 > 0.7). None of them were associated with PD risk. Among women, however, there was a suggestion that the presence of the minor allele of one SNP (rs7442295) was related to a small increase in PD risk [OR (95% CI) = 1.48 (1.01-2.16)].

Conclusion

This study provides little support for genetic variations of SLC2A9 and PD risk.