Most Recent Articles: Translational Neurodegenerationhttps://translationalneurodegeneration.biomedcentral.comMost Recent Articles: Translational NeurodegenerationOverlaps and divergences between tauopathies and synucleinopathies: a duet of neurodegenerationhttps://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-024-00407-yProteinopathy, defined as the abnormal accumulation of proteins that eventually leads to cell death, is one of the most significant pathological features of neurodegenerative diseases. Tauopathies, represented...ReviewTue, 26 Mar 2024 00:00:00 GMThttps://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-024-00407-yWen Li and Jia-Yi Li2024-03-26T00:00:00ZBiases in α-synuclein immuno-quantitation: a core problem for basic and ancillary studies of Parkinson’s disease and multiple system atrophyhttps://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-024-00408-xLetterMon, 25 Mar 2024 00:00:00 GMThttps://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-024-00408-xFlorent Laferrière, Ludivine Sabatier, Stéphane Claverol, Francesca De Giorgi and François Ichas2024-03-25T00:00:00ZPutative novel CSF biomarkers of Alzheimer’s disease based on the novel concept of generic protein misfolding and proteotoxicity: the PRAMA cohorthttps://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-024-00405-0LetterFri, 08 Mar 2024 00:00:00 GMThttps://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-024-00405-0Alessandra Bigi, Giulia Fani, Valentina Bessi, Liliana Napolitano, Silvia Bagnoli, Assunta Ingannato, Lorenzo Neri, Roberta Cascella, Paolo Matteini, Sandro Sorbi, Benedetta Nacmias, Cristina Cecchi and Fabrizio Chiti2024-03-08T00:00:00ZLRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progressionhttps://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-024-00403-2Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). These mutations elevate the LRRK2 kinase activity, making LRRK2 kinase inhibitors an attractive th...ResearchMon, 04 Mar 2024 00:00:00 GMThttps://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-024-00403-2Noah Lubben, Julia K. Brynildsen, Connor M. Webb, Howard L. Li, Cheryl E. G. Leyns, Lakshmi Changolkar, Bin Zhang, Emily S. Meymand, Mia O’Reilly, Zach Madaj, Daniella DeWeerd, Matthew J. Fell, Virginia M. Y. Lee, Dani S. Bassett and Michael X. Henderson2024-03-04T00:00:00ZTherapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedsidehttps://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-024-00404-1The aetiologies and origins of neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD), are complex and multifa...ReviewTue, 27 Feb 2024 00:00:00 GMThttps://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-024-00404-1Yuan-Yuan Ma, Xin Li, Jin-Tai Yu and Yan-Jiang Wang2024-02-27T00:00:00Z